Olea South: (07) 3808 8624 | Olea North: (07) 3325 5512
Olea South: (07) 3808 8624
Olea North: (07) 3325 5512

Pyrroles Disorder, Testing and Treatment in Brisbane

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Pyrrole Problems? Do you have any of the following symptoms?

Do you have Pyrroles Disorder?

Originally identified in the 1950s by Dr Abram Hoffer, Dr Humphrey Osmond and Dr Carl Pfeiffer, pyrrole disorder, or pyroluria, refers to a condition that results in an overproduction of pyrroles or hydroxyhaemopyrrolin-2-one (HPL). HPL is a by-product of haemoglobin (Hb) synthesis and the disorder reflects an abnormality in the synthesis and metabolism of Hb

Pyrrole disorder, also known as mauve factor, kryptopyrroluria and pyrroluria, is not commonly heard about but is now presenting more often.

If you suffer from pyrrole disorder, you are more likely to suffer from associated mood disorders and poor immunity. There is evidence that pyrrole disorder is found in 10-20% of the general population and as high as 35-45% in people with mood disorders, autism, schizophrenia and bipolar disorder.

Pyrrole disorder also has a genetic predisposition and can be brought on when stress, emotional or environmental, causes an imbalance in your body’s biochemistry. It is a marker of oxidative stress and leaky gut often is a contributing factor.

Symptoms manifest as vitamin B6 and zinc deficiency

HPL binds several nutrient cofactors, in particular vitamin B6 and zinc, essentially rendering them unavailable for use by the body.   B6 and zinc are critical for digestion, immune function, cognition and emotion, and chronic depletion can have serious consequences on wellbeing. The signs and symptoms of pyrrole disorder correlate with a deficiency of B6 and zinc.   A combination of physical, emotional and cognitive symptoms as well as stress are associated with pyroluria, so it is important to consider that not everyone that exhibits these symptoms will have pyrrole disorder, and not everyone with the disorder will have all of the symptoms.   Some of the symptoms of pyrrole disorder may include:

  • poor dream recall
  • mid-morning nausea
  • poor morning appetite
  • white spots on nails
  • stretch marks
  • pale complexion
  • digestive complaints
  • joint and/or skin complaints
  • anxiety
  • mood swings
  • sensitivity to noise and lights
  • histrionic (dramatic]
  • Difficulty concentrating
  • Poor memory short-term
  • Fatigue
  • Poor stress control
  • Gastrointestinal (tummy) disorders
  • Headaches
  • Insomnia
  • Joint pains
  • Poor stress control
  • Mood swings
  • Nervousness and/or anxiety

Pyrroles, officially called hydroxyhemopyrrolin-2-one or HPL, are by-products of the production of haemoglobin in your red blood cells (the part that carries oxygen around your body).  They are normally produced in your body however; higher levels of them can affect the utilisation of particular nutrients and create the symptoms referred to above.  Also known as Mauve Factor (due to the mauve colour visible on testing paper during urinalysis) or pyrrole disorder, pyroluria occurs when the pyrroles bind to pyroxidine (vitamin B6) and zinc, causing these vital nutrients to be excreted from the body in large amounts.

Genetic basis

There is evidence that pyrrole disorder is a genetic condition. If one parent has pyrrole disorder then there is a 50% chance that it may be passed onto a child. If both parents are affected then there is a 75% chance of inheriting the disorder.    Pyrrole disorder should also be considered in patients who may not respond to medications such as SSRIs and antipsychotics but show improvement with nutritional therapy.

So What Can You Do?

At Olea Health we regularly test for Pyrroles, using a urine sample through a local Brisbane Laboratory.  Tests can also be arranged for patients outside the Brisbane area through our local pathology providers.    On receipt of your test results we are able to prescribe specific nutrients for your individual needs and then continue to closely monitor your body’s reaction until you receive relief from your pyrroles condition.

For more information please contact us at Olea Springwood ph 3808 8627 or Olea Eatons Hill ph 3325 5512   Help is available!


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